Research Paper Volume 11, Issue 17 pp 7274—7293

The activation of cardiac dSir2-related pathways mediates physical exercise resistance to heart aging in old Drosophila

Figure 7. Effect of exercise and cardiac Sir2 on the climbing index and average lifespan in Drosophila. (A) The climbing index. The sample size was about 100 flies for each group. (B) The average lifespan. The sample size was 200–220 flies for each group. (C) Percents of survival curve. The rightmost curve represents the cardiac dSir2 overexpression combined with exercise group, of which flies had the longest lifespan. P-values for lifespan curves were calculated by the log-rank test. Data are represented as means ± SEM. *P<0.05; **P <0.01.