Research Paper Volume 11, Issue 18 pp 7678—7693

Long noncoding RNA TTN-AS1 enhances the malignant characteristics of osteosarcoma by acting as a competing endogenous RNA on microRNA-376a thereby upregulating dickkopf-1

Figure 4. MiR-376a exerts a tumor-suppressive action on the growth and metastasis of HOS and MG-63 cells. (A, B) The CCK-8 assay and flow cytometry uncovered a change in proliferation and apoptosis of miR-376a-overexpressing HOS and MG-63 cells. *P < 0.05 vs. group agomir-NC. (C, D) HOS and MG-63 cells were treated with either agomir-376a or agomir-NC. After the transfection, Transwell migration and invasion assays were carried out. *P < 0.05 vs. group agomir-NC.