Figure 2. The expression of DEGs in vitro and in vivo. (A) The relative expression of PRKACA, CREB3 and GNAO1 in the tumor tissues and adjacent normal tissues of patients with glioblastoma (n = 60). (B) ROC curves of varying sensitivity and specificity. The closer the curve is to point “a” (x = 0, y = 100%), the more sensitive and specific the experiment is. (C) Pretreatment parameters as predictors of relapse-free survival in patients with glioblastoma. (D) The probability of overall survival in low-CREB3 and high-CREB3 groups. **P<0.01 compared with the normal group.