Research Paper Volume 11, Issue 19 pp 8156—8168

Knockdown of CREB3 activates endoplasmic reticulum stress and induces apoptosis in glioblastoma

Figure 9. The downregulation of CREB3 activated ERS pathway proteins in tumor tissues. (A) The levels of CREB3, p-PERK, p-eIF2α and ATF4 in tumor tissues were detected by Western blotting. (BE) The relative levels of CREB3 (B), p-PERK (C), p-eIF2α (D) and ATF4 (E) were quantified and normalized to β-actin levels. **P<0.01 compared with the NC group.