Figure 9. The downregulation of CREB3 activated ERS pathway proteins in tumor tissues. (A) The levels of CREB3, p-PERK, p-eIF2α and ATF4 in tumor tissues were detected by Western blotting. (B–E) The relative levels of CREB3 (B), p-PERK (C), p-eIF2α (D) and ATF4 (E) were quantified and normalized to β-actin levels. **P<0.01 compared with the NC group.