Research Paper Volume 11, Issue 19 pp 8169—8182

Figure 7. Functional enrichment analysis of KCNKs through STRING database. We analyzed the network of KCNK mutations and their 50 most frequently altered neighboring genes; sodium channels SCN1A, SCN2A, SCN3A, SCN5A, SCN8A, SCN9A, SCN10A, and SCN11A, and calcium channel subunits CACNA1C, CACNA1D, CACNA1F, CACNB1, CACNB2, and CACNB3 were associated with KCNK mutations (A). GO and KEGG functional enrichment analysis showed that voltage-gated ion transport and ion transmembrane transport function, action channel activity function, adrenergic signaling pathway, oxytocin signaling pathway, and hypertrophic cardiomyopathy were compromised by mutations in the KCNK2/9/15/17 genes (B, C, D, E).