Research Paper Volume 11, Issue 19 pp 8204—8216

SNHG22 overexpression indicates poor prognosis and induces chemotherapy resistance via the miR-2467/Gal-1 signaling pathway in epithelial ovarian carcinoma

Figure 2. High SNHG22 expression promotes EOC cell chemoresistance in vitro. (A) SNHG22 expression in several EOC cell lines was examined using qRT-PCR analysis. GAPDH was used as an internal loading control. (B) SNHG22 expression in EOC SKOV3 and A2780/CP cells was modified by shRNA transfection. (C) SNHG22 expression in EOC Hey and OAW28 cells was modified by mock-lentivirus or SNHG22-lentivirus transfection. (DG) Cisplatin or paclitaxel sensitivity was measured using CCK-8 assays in EOC cells. Data are presented as the means ± SDs in three independent experiments. *P < 0.05, **P < 0.01, ***P < 0.001.