Research Paper Volume 11, Issue 19 pp 8239—8253

The long non-coding RNA, urothelial carcinoma associated 1, promotes cell growth, invasion, migration, and chemo-resistance in glioma through Wnt/β-catenin signaling pathway

Figure 6. UCA1 promoted chemo-resistance in glioma cells. The IC50 of cisplatin for (A) U87 and (B) SHG139 cell lines in negative control (pcDNA3.1), UCA1 (pcDNA3.1-UCA1), and UCA1 (pcDNA3.1-UCA1) + XAV939 groups was determined by CCK-8 assay. The IC50 of cisplatin for (C) U87 and (D) SHG139 cell lines in negative control (scrambled siRNA), siUCA1(a), siUCA1(a) + LiCl groups was determined by CCK-8 assay. The IC50 of TMZ for (E) U87 and (F) SHG139 cell lines in negative control (pcDNA3.1), UCA1 (pcDNA3.1-UCA1), and UCA1 (pcDNA3.1-UCA1) + XAV939 groups was determined by CCK-8 assay. The IC50 of TMZ for (G) U87 and (H) SHG139 cell lines in negative control (scrambled siRNA), siUCA1(a), siUCA1(a) + LiCl groups was determined by CCK-8 assay. All the experiments were performed in triplicates. Significant differences compared to the control group were expressed as *P<0.05, **P<0.01 and ***P<0.01.