Research Paper Volume 11, Issue 19 pp 8347—8361

Gomisin M2 from Baizuan suppresses breast cancer stem cell proliferation in a zebrafish xenograft model

Figure 7. Gomisin M2 inhibits tumor growth in zebrafish. Cancer stem cells enriched MDA-MB-231-GFP (green) (A) or HCC1806 (red) (B) cells were microinjected into zebrafish embryos (larvae stage, n = 30 per group). Fluorescence density was captured by fluorescence microscopy at 0, 24 and 48 h after implantation. (C) The quantitative data of panel A in green fluorescence intensity. (D) The quantitative data of panel B in red fluorescence intensity. *p < 0.05, **p < 0.01, ***p < 0.001. (E) Statistical analysis of panel A and B the percentages of embryos without proliferation in control and Gomisin M2 groups in 48 h.