Research Paper Volume 11, Issue 19 pp 8347—8361

Gomisin M2 from Baizuan suppresses breast cancer stem cell proliferation in a zebrafish xenograft model

Figure 8. Gomisin M2 downregulates the Wnt/β-Catenin pathway in breast cancer cells. The effects of Gomisin M2 on expression levels of cyclin D1, β-catenin, GSK3-β, p-β-catenin, and p-GSK3β in MDA-MB-231 (A) and HCC1806 (B) cells. Cells were stimulated with increasing doses of Gomisin M2 for 48 h, and the same dose was applied at different time points. The experiment was repeated thrice with similar results.