Research Paper Volume 11, Issue 19 pp 8374—8385

LncRNA TTN-AS1 regulates osteosarcoma cell apoptosis and drug resistance via the miR-134-5p/MBTD1 axis

Figure 1. lncRNA TTN-AS1 is highly expressed in osteosarcoma and is associated with poor prognosis. (A) Bioinformatics analysis of differentially expressed genes in osteosarcoma. (B) QPCR was used to detect the expression level of lncRNA TTN-AS1 in tumour tissues and adjacent tissues. (C) QPCR was applied to detect lncRNA TTN-AS1 levels in osteosarcoma cell lines. (D) 5-year survival analysis was done on osteosarcoma patients with different lncRNA TTN-AS1 levels. *P < 0.05 vs. normal tissue or hFOB 1.19 cell group;