Research Paper Volume 11, Issue 19 pp 8374—8385

LncRNA TTN-AS1 regulates osteosarcoma cell apoptosis and drug resistance via the miR-134-5p/MBTD1 axis

Figure 7. Downregulation of lncRNA TTN-AS1 reduces drug resistance. (A, B) The effects of different concentrations of cisplatin on the viability of osteosarcoma cells are shown. (C, D) Downregulation of lncRNA TTN-AS1 enhanced the inhibitory effects of cisplatin on osteosarcoma cells. (E, F) Upregulation of lncRNA TTN-AS1 attenuated the inhibitory effect of cisplatin on osteosarcoma cells. *P < 0.05 vs. sh-NC and vector-NC group of 0 μM; #P < 0.05 vs. sh-NC and vector-NC group of 10 μM.