Research Paper Volume 11, Issue 19 pp 8433—8462

Brain pyrimidine nucleotide synthesis and Alzheimer disease

Figure 5. Expression of genes encoding (A) DHODH and (B) UCK2 proteins from both pyrimidine nucleotide synthesis pathways. GAPDH mRNA levels have been used to normalize. CA1: hippocampal cornus ammon 1; EC: entorhinal cortex; DG: dentate gyrus; LC: locus ceruleus. Points represent individual samples and horizontal lines indicate mean ± standard deviation values. P values for Kruskal-Wallis tests are indicated under the graphs. Horizontal red lines indicate between-regions p values (p < 0.0083) fulfilling the post-hoc Bonferroni/Dunn criteria.