Research Paper Volume 11, Issue 19 pp 8433—8462

Brain pyrimidine nucleotide synthesis and Alzheimer disease

Figure 9. mRNA levels of selected genes encoding proteins from both pyrimidine nucleotide synthesis pathways. Graphs represent mean ± standard deviation values of UCK2 (AD), DHODH (EH), and DHODH - UCK2 correlations (IL); respectively. GAPDH mRNA levels have been used to normalize. CA1: hippocampal cornus ammon 1; EC: entorhinal cortex; DG: dentate gyrus; LC: locus ceruleus. Each point represents an individual sample. The p values for Kruskal-Wallis or ANOVA tests are indicated under the graphs. Red and black horizontal lines indicate significant p values, fulfilling (p < 0.0083, p < 0.0167 in LC) or no (p ≤ 0.05) the post-hoc Bonferroni/Dunn criteria.