Research Paper Volume 11, Issue 19 pp 8542—8555

Probucol, a “non-statin” cholesterol-lowering drug, ameliorates D-galactose induced cognitive deficits by alleviating oxidative stress via Keap1/Nrf2 signaling pathway in mice


Figure 1. Effect of Prob on plasma cholesterol, organ index and general appearance in mice. (A) Effect of Prob on plasma cholesterol level. (B, C) Effect of Prob on body weight and food consumption of mice, respectively. (D) The representative picture of liver, kidney and spleen of mice. (EG) Effect of Prob on liver, kidney and splenic organ index, respectively. Data in each experiment represent mean ± SEM from 10 independent samples. Statistically significant differences were calculated by one-way ANOVA using the SPSS 20.0 software. *P<0.05 and ** P<0.01, versus D-gal group.