Probucol, a “non-statin” cholesterol-lowering drug, ameliorates D-galactose induced cognitive deficits by alleviating oxidative stress via Keap1/Nrf2 signaling pathway in mice

Jin-Lan Huang; Chao Yu; Min Su; Si-Man Yang; Fan Zhang; Yuan-Yuan Chen; Jin-Yuan Liu; Yi-Fan Jiang; Zhen-Guo Zhong; Deng-Pan Wu

doi:doi:10.18632/aging.102337

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Research Paper Volume 11, Issue 19 pp 8542—8555

Probucol, a “non-statin” cholesterol-lowering drug, ameliorates D-galactose induced cognitive deficits by alleviating oxidative stress via Keap1/Nrf2 signaling pathway in mice

Figure 5. Effect of Prob on SOD, GSH-PX and HO-1 expression. (A–C) SOD, GSH-PX and HO-1 mRNA expression, respectively. (D–F) SOD, GSH-PX and HO-1 protein expression, respectively. Data in each experiment represent mean ± SEM from 10 independent samples. Statistically significant differences were calculated by one-way ANOVA using the SPSS 20.0 software. ** P<0.01, versus D-gal group.