Research Paper Volume 11, Issue 19 pp 8556—8572

Conserved aging-related signatures of senescence and inflammation in different tissues and species

Figure 1. A t-distributed stochastic neighbor embedding (t-SNE) of the analyzed RNA-Seq libraries. All RNA-Seq samples were clustered based on the expression patterns of the selected senescence and inflammation related genes, utilizing the t-SNE approach. All tissues form distinctive species-specific and non-overlapping clusters with exception to very few single outliers. Additionally, larger species-independent tissue clusters were drawn to improve the visualization of the data. However, the three different time points did not generally separate in independent clusters of their own. A weak segregation can only be observed among the mature and old-aged skin samples of all four species. For more information, see Supplementary Data 10.