Research Paper Volume 11, Issue 19 pp 8587—8603

A molecular sub-cluster of colon cancer cells with low VDR expression is sensitive to chemotherapy, BRAF inhibitors and PI3K-mTOR inhibitors treatment

Figure 1. CMS3 subtype colon cancer cells are more sensitive to 5-Fluorouracil treatment and CMS4 subtype colon cancer cells are more sensitive to cisplatin treatment. (A) Colon cancer cell lines were divided into CMS subtypes based on the gene expression profiling using CMScaller. Number of colon cancer cell lines in each CMS subtype was demonstrated. (B) A template feature of the CMS subtypes. (C) Contingency graphs showed the number of MSI or MSS subtype, BRAF, K-Ras and APC mutant or wild type colon cancer cell lines in each CMS subtype. P values were determined by Chi-square test. (D) Box plots showed the LN-IC50 of chemotherapy drugs cisplatin, docetaxel and 5-Fluorouracil in CMS2, CMS3 and CMS4 subtypes of colon cancer cells. P values were performed using Student’s t test. (E) Box plots showed the LN-IC50 of EGFR inhibitors in CMS2, CMS3 and CMS4 subtypes of colon cancer cells.