Research Paper Volume 11, Issue 19 pp 8587—8603

A molecular sub-cluster of colon cancer cells with low VDR expression is sensitive to chemotherapy, BRAF inhibitors and PI3K-mTOR inhibitors treatment

Figure 2. Chemo-sensitivity is different in the three sub-clusters of colon cancer cell lines classified by NMF. (A) Colon cancer cell lines were divided into two, three or four sub-clusters based on the gene expression profiling using NMF. Number of colon cancer cell lines in each sub-cluster was demonstrated. (B) Consensus maps showed the correlation profilings of colon cancer cell lines from two consensuses, three consensuses or four consensuses. (C) Box plots showed the LN-IC50 of chemotherapy drugs cisplatin, docetaxel and 5-Fluorouracil in each sub-cluster derived from two consensuses, three consensuses or four consensuses. (D) Box plots showed the LN-IC50 of EGFR inhibitors in each colon cancer sub-cluster derived from three consensuses.