Research Paper Volume 11, Issue 19 pp 8587—8603

A molecular sub-cluster of colon cancer cells with low VDR expression is sensitive to chemotherapy, BRAF inhibitors and PI3K-mTOR inhibitors treatment

Figure 5. Lack of CDX2 expression is associated with the sensitivity of chemotherapy, BRAF inhibitors and PI3K-mTOR inhibitors. (A) Box plots showed the CDX2 expression in each sub-cluster of colon cancer cells. (B) Box plots showed the CDX2 expression in docetaxel, cisplatin, PIK-93 sensitive and resistant colon cancer cells. (C) Relationships of CDX2 expression and overall survival were analyzed from GSE17536 and GSE39582 datasets. Kaplan Meier survival analysis was used to compare the overall survival between CDX2 highly expressed colon cancer patients and CDX2 lowly expressed colon cancer patients. P values were determined by Log-rank test.