Research Paper Volume 11, Issue 19 pp 8587—8603

A molecular sub-cluster of colon cancer cells with low VDR expression is sensitive to chemotherapy, BRAF inhibitors and PI3K-mTOR inhibitors treatment

Figure 8. Validation of NMF sub-cluster classification in colon cancer clinical patients. (A) Primary colon cancer patients from GSE24551, GSE33113, GSE17536 and GSE39582 datasets were divided into three or four sub-clusters based on the gene expression profiling using NMF. Kaplan Meier survival analysis was used to determine the disease free survival or overall survival in three or four sub-clusters of colon cancer patients. (B) Box plots showed the CDX2 and VDR expression in each sub-cluster of colon cancer patients.