Research Paper Volume 11, Issue 19 pp 8623—8641

TRIM59 loss in M2 macrophages promotes melanoma migration and invasion by upregulating MMP-9 and Madcam1

Figure 7. MMP-9 or Madcam1 silencing decreases pulmonary metastasis of melanoma cells. Representative macroscopic and H&E images of mouse lungs colonized by metastatic B16-F10 melanoma cells. Scale bar = 20 μm. Quantification of metastatic foci (mean ± SD, n = 5) for each experimental condition is shown. Data are represented as mean ± SD. *p<0.05, **p<0.01, compared with shRNA control B16-F10 cells inoculated in TRIM59-CKO mice.