Research Paper Volume 11, Issue 19 pp 8642—8663

Decreased levels of circulating trimethylamine N-oxide alleviate cognitive and pathological deterioration in transgenic mice: a potential therapeutic approach for Alzheimer’s disease

Figure 1. Age-related senescence and cognitive impairments in WT and APP/PS1 mice. The senescence degree (A), nest building score (B), and spontaneous locomotor activity (C) of WT and APP/PS1 mice. The preferential index (time on novel object C/(time on novel object C+time on sample object A)×100%) after training 1 hour (D) in the phase of novel object test. Latency, the first time that the mice crossed the former platform in the learning task of the Morris water maze test (E). The successful avoidance times in testing phase of shuttle box test (F). *P<0.05, **P<0.01, ***P<0.001, versus the age-matched WT mice, aP<0.05, versus 3-month-old syngeneic mice, bP<0.05, versus 6-month-old syngeneic mice, cP<0.05, versus 9-month-old syngeneic mice by two-way repeated-measures analyses of variance with Tukey multiple comparisons tests. All values are means ± S.D. n=10.