Figure 2. Age-related decline of long-term potentiation (LTP) in APP/PS1 mice. The magnitude of LTP in WT and APP/PS1 mice (A). High-frequency stimulation (HFS) was given at the 30 minutes of population spike (PS) baseline recording, and PS was recorded for the following 60 minutes. The average PS amplitudes in the control period were normalized as 100%, and the PS amplitudes at every point were normalized to them. Summary of average PS amplitude (31–90 minutes) in WT and APP/PS1 mice (B). ***P<0.001, versus the age-matched WT mice, aP<0.05, versus 3-month-old syngeneic mice, bP<0.05, versus 6-month-old syngeneic mice, cP<0.05, versus 9-month-old syngeneic mice by one-way ANOVA analysis followed by Dunnett’s post hoc test. All values are means ± S.D. n=10.