Research Paper Volume 11, Issue 19 pp 8642—8663

Decreased levels of circulating trimethylamine N-oxide alleviate cognitive and pathological deterioration in transgenic mice: a potential therapeutic approach for Alzheimer’s disease

Figure 3. Age-related pathological deterioration in the hippocampus of APP/PS1 mice. Representative immunofluorescence staining images showing Αβ plaques (green and indicated by red arrows) and Nissl staining images showing Nissl bodies in the hippocampus of WT and APP/PS1 mice (A). Quantification of Αβ plaques(B) in the hippocampus of WT and APP/PS1 mice. Quantification of and Nissl bodies in the hippocampus (C), CA1 (D), CA3 (E) and DG (F) regions of WT and APP/PS1 mice. Quantitative analysis was used by Image Pro Plus 6.0 software. *P<0.05, **P<0.01, ***P<0.001, versus the age-matched WT mice, aP<0.05, versus 3-month-old syngeneic mice, bP<0.05, versus 6-month-old syngeneic mice, cP<0.05, versus 9-month-old syngeneic mice by two-way repeated-measures analyses of variance with Tukey multiple comparisons tests. All values are means ± S.D. n=10.