Research Paper Volume 11, Issue 19 pp 8642—8663

Decreased levels of circulating trimethylamine N-oxide alleviate cognitive and pathological deterioration in transgenic mice: a potential therapeutic approach for Alzheimer’s disease

Figure 7. Effects of DMB on cognitive impairments in WT and APP/PS1 mice. The spontaneous locomotor activity (A), preferential index after training 1 hour in the phase of novel object test (B), latency in the testing task of Morris water maze test (E), successful avoidance times in testing phase of shuttle box test (D), magnitude of LTP (E) and summary of average PS amplitude (F) in WT and APP/PS1 mice. *P<0.05, ***P<0.001, versus the WT+ NT mice, #P<0.05, ###P<0.001, versus the APP/PS1+ NT mice, $P<0.05, $$$P<0.001, versus the WT+DMB mice by one-way ANOVA analysis followed by Dunnett’s post hoc test. All values are means ± S.D. n=10. NT means no treatment.