Research Paper Volume 11, Issue 19 pp 8642—8663

Decreased levels of circulating trimethylamine N-oxide alleviate cognitive and pathological deterioration in transgenic mice: a potential therapeutic approach for Alzheimer’s disease

Figure 8. Effects of DMB on the levels of amyloid-β (Aβ) in WT and APP/PS1 mice. The concentration of Aβ1-42 and Aβ1-40 in the hippocampus (A and B) and plasma (C and D) of WT and APP/PS1 mice. The concentration of β-secretase (E), β-secretase-cleaved C-terminal fragment (βCTF) (F) and γ-secretase (E) in the hippocampus of WT and APP/PS1 mice. ***P<0.001, versus the WT+ NT mice, #P<0.05, ##P<0.01, ###P<0.001, versus the APP/PS1+ NT mice, $$P<0.01, $$$P<0.001, versus the WT+DMB mice by one-way ANOVA analysis followed by Dunnett’s post hoc test. All values are means ± S.D. n=10. NT means no treatment.