Research Paper Volume 11, Issue 22 pp 9982—9999

Circular RNA hsa_circ_0000515 acts as a miR-326 sponge to promote cervical cancer progression through up-regulation of ELK1

Figure 7. Hsa_circ_0000515 silencing in vivo inhibits tumor growth in nude mice. (A) tumors formed in nude mice at 21st d; (B) tumor growth curve of nude mice; (C) tumor weight in nude mice at 21st d; (D) immunohistochemical detection of MVD density in tumor tissues of nude mice; (E) the immunohistochemical detection of Ki67 in tumor tissues of nude mice (400 ×); (F) cell apoptosis in tumor tissues assessed by TUNEL staining (200 ×); *p < 0.05 vs. the si-NC group; measurement data were expressed as mean ± standard deviation; unpaired t test was used to compare data with normal distribution and equal variance between two groups; data at different time points were compared by repeated measures analysis of variance, with Bonferroni post-test; N=10.