Volume 11, Issue 22

30 November, 2019
pp 9961—10782

About the Cover

The cover features Figure 4 "Using age predictors within specified age groups to infer causality and identify therapeutic interventions" from Zhavoronkov et al.

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Editorials

Colon importance in short bowel syndrome

Cecile Lambe, Olivier Goulet, Lorenzo Norsa,

https://doi.org/10.18632/aging.102447 pp 9961—9962

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Chronic stress and energy homoeostasis

Chi Kin Ip, Herbert Herzog, Lei Zhang,

https://doi.org/10.18632/aging.102500 pp 9963—9964

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Aging and atrial fibrillation: a matter of fibrosis

Susana Ravassa, Gabriel Ballesteros, Javier Díez,

https://doi.org/10.18632/aging.102501 pp 9965—9966

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β-cell senescence in type 2 diabetes

Cristina Aguayo-Mazzucato, Ayush Midha,

https://doi.org/10.18632/aging.102502 pp 9967—9968

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Reduced lymphatic function contributes to age-related disease

Gaurav Baranwal, Joseph M. Rutkowski,

https://doi.org/10.18632/aging.102503 pp 9969—9970

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Meeting Report

Latest advances in aging research and drug discovery

Daniela Bakula, Andrea Ablasser, Adriano Aguzzi, Adam Antebi, Nir Barzilai, Martin-Immanuel Bittner, Martin Borch Jensen, Cornelis F. Calkhoven, Danica Chen, Aubrey D.N.J. de Grey, Jerome N. Feige, Anastasia Georgievskaya, Vadim N. Gladyshev, Tyler Golato, Andrei V. Gudkov, Thorsten Hoppe, Matt Kaeberlein, Pekka Katajisto, Brian K. Kennedy, Unmesh Lal, Ana Martin-Villalba, Alexey A. Moskalev, Ivan Ozerov, Michael A. Petr, Reason, David C. Rubinsztein, Alexander Tyshkovskiy, Quentin Vanhaelen, Alex Zhavoronkov, Morten Scheibye-Knudsen,

https://doi.org/10.18632/aging.102487 pp 9971—9981

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Research Papers

Circular RNA hsa_circ_0000515 acts as a miR-326 sponge to promote cervical cancer progression through up-regulation of ELK1

Qiu Tang, Zhigang Chen, Liangping Zhao, Hai Xu,

https://doi.org/10.18632/aging.102356 pp 9982—9999

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Mapping the patterns of cortical thickness in single- and multiple-domain amnestic mild cognitive impairment patients: a pilot study

Pan Sun, Wutao Lou, Jianghong Liu, Lin Shi, Kuncheng Li, Defeng Wang, Vincent CT Mok, Peipeng Liang,

https://doi.org/10.18632/aging.102362 pp 10000—10015

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Silencing of long non-coding RNA H19 downregulates CTCF to protect against atherosclerosis by upregulating PKD1 expression in ApoE knockout mice

Yongyao Yang, Feng Tang, Fang Wei, Long Yang, Chunyan Kuang, Hongming Zhang, Jiusheng Deng, Qiang Wu,

https://doi.org/10.18632/aging.102388 pp 10016—10030

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DNA methylation profile is a quantitative measure of biological aging in children

Xiaohui Wu, Weidan Chen, Fangqin Lin, Qingsheng Huang, Jiayong Zhong, Huan Gao, Yanyan Song, Huiying Liang,

https://doi.org/10.18632/aging.102399 pp 10031—10051

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Late stage gastric cancer patients with extra gained HER2 positivity by dual block assessment may not show compromised efficacy to trastuzumab treatment

Chen Xu, Yalan Liu, Dongxian Jiang, Xiaowen Ge, Jie Huang, Jieakesu Su, Xue Zhang, Shaohua Lu, Yuan Ji, Jun Hou, Tianshu Liu, Yingyong Hou,

https://doi.org/10.18632/aging.102415 pp 10052—10060

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PGC1α activation by pterostilbene ameliorates acute doxorubicin cardiotoxicity by reducing oxidative stress via enhancing AMPK and SIRT1 cascades

Dong Liu, Zhiqiang Ma, Liqun Xu, Xiaoyan Zhang, Shubin Qiao, Jiansong Yuan,

https://doi.org/10.18632/aging.102418 pp 10061—10073

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Characterization of long non-coding RNA and messenger RNA profiles in laryngeal cancer by weighted gene co-expression network analysis

Huanhuan Liu, Yi Sun, Huan Tian, Xiaolian Xiao, Jiaqi Zhang, Yongzhen Wang, Fengyan Yu,

https://doi.org/10.18632/aging.102419 pp 10074—10099

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Decreased inter-hemispheric interactions but increased intra-hemispheric integration during typical aging

Qunlin Chen, Yunman Xia, Kaixiang Zhuang, Xinran Wu, Guangyuan Liu, Jiang Qiu,

https://doi.org/10.18632/aging.102421 pp 10100—10115

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The construction and analysis of tumor-infiltrating immune cell and ceRNA networks in recurrent soft tissue sarcoma

Runzhi Huang, Tong Meng, Rui Chen, Penghui Yan, Jie Zhang, Peng Hu, Xiaolong Zhu, Huabin Yin, Dianwen Song, Zongqiang Huang,

https://doi.org/10.18632/aging.102424 pp 10116—10143

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Long noncoding RNA LINC00899 suppresses breast cancer progression by inhibiting miR-425

Wenying Zhou, Jiao Gong, Yaqiong Chen, Jiahao Chen, Qi Zhuang, Jing Cao, Zhixiong Mei, Bo Hu,

https://doi.org/10.18632/aging.102426 pp 10144—10153

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Prognostic genes in the tumor microenvironment in cervical squamous cell carcinoma

Xin-Bin Pan, Yan Lu, Jian-Li Huang, Ying Long, De-Sheng Yao,

https://doi.org/10.18632/aging.102429 pp 10154—10166

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Tissue plasminogen activator disrupts the blood-brain barrier through increasing the inflammatory response mediated by pericytes after cerebral ischemia

Eryan Yang, Ying Cai, Xiuhua Yao, Ji Liu, Qixue Wang, Weili Jin, Qiaoli Wu, Weijia Fan, Lina Qiu, Chunsheng Kang, Jialing Wu,

https://doi.org/10.18632/aging.102431 pp 10167—10182

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Development and validation of a metastasis-associated prognostic signature based on single-cell RNA-seq in clear cell renal cell carcinoma

Chuanjie Zhang, Hongchao He, Xin Hu, Ao Liu, Da Huang, Yang Xu, Lu Chen, Danfeng Xu,

https://doi.org/10.18632/aging.102434 pp 10183—10202

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Mitochondrial fission regulator 2 (MTFR2) promotes growth, migration, invasion and tumour progression in breast cancer cells

Guanming Lu, Yuanhui Lai, Tiantian Wang, Weihao Lin, Jinlan Lu, Yanfei Ma, Yongcheng Chen, Haiqing Ma, Ruilei Liu, Jie Li,

https://doi.org/10.18632/aging.102442 pp 10203—10219

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Circular RNA CircCCNB1 sponges micro RNA-449a to inhibit cellular senescence by targeting CCNE2

Ai Qing Yu, Zhi Xiao Wang, Wu Wu, Ke Yu Chen, Shi Rong Yan, Ze Bin Mao,

https://doi.org/10.18632/aging.102449 pp 10220—10241

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Studies on APP metabolism related to age-associated mitochondrial dysfunction in APP/PS1 transgenic mice

Lizhi Chen, Shicheng Xu, Tong Wu, Yijia Shao, Li Luo, Lingqi Zhou, Shanshan Ou, Hai Tang, Wenhua Huang, Kaihua Guo, Jie Xu,

https://doi.org/10.18632/aging.102451 pp 10242—10251

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Metformin decreases LPS-induced inflammatory response in rabbit annulus fibrosus stem/progenitor cells by blocking HMGB1 release

Yingchao Han, Feng Yuan, Chao Deng, Fan He, Yan Zhang, Hongxing Shen, Zhi Chen, Lie Qian,

https://doi.org/10.18632/aging.102453 pp 10252—10265

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Silencing lncRNA FOXD2-AS1 inhibits proliferation, migration, invasion and drug resistance of drug-resistant glioma cells and promotes their apoptosis via microRNA-98-5p/CPEB4 axis

Naibing Gu, Xinlai Wang, Zhengli Di, Jing Xiong, Yue Ma, Yu’e Yan, Yihua Qian, Quanzeng Zhang, Jia Yu,

https://doi.org/10.18632/aging.102455 pp 10266—10283

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The anti-carcinogenesis properties of erianin in the modulation of oxidative stress-mediated apoptosis and immune response in liver cancer

Xinrui Zhang, Yingwu Wang, Xin Li, Anhui Yang, Zhiwen Li, Di Wang,

https://doi.org/10.18632/aging.102456 pp 10284—10300

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Combined test of third lumbar skeletal muscle index and prognostic nutrition index improve prognosis prediction power in resected colorectal cancer liver metastasis

Yang Lv, Mei-Ling Ji, Qing-Yang Feng, De-Xiang Zhu, Song-Bin Lin, Yi-Hao Mao, Yu-Qiu Xu, Peng Zheng, Guo-Dong He, Jian-Min Xu,

https://doi.org/10.18632/aging.102457 pp 10301—10315

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Multi-omics analysis reveals epithelial-mesenchymal transition-related gene FOXM1 as a novel prognostic biomarker in clear cell renal carcinoma

Jing Song, Fangzhou Song, Kun Liu, Wanfeng Zhang, Ruihan Luo, Yongyao Tang, Longke Ran,

https://doi.org/10.18632/aging.102459 pp 10316—10337

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GBA mutation promotes early mitochondrial dysfunction in 3D neurosphere models

Constanza Morén, Diana Luz Juárez-Flores, Kai-Yin Chau, Matthew Gegg, Glòria Garrabou, Ingrid González-Casacuberta, Mariona Guitart-Mampel, Eduardo Tolosa, María José Martí, Francesc Cardellach, Anthony Henry Vernon Schapira,

https://doi.org/10.18632/aging.102460 pp 10338—10355

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Folic acid delays age-related cognitive decline in senescence-accelerated mouse prone 8: alleviating telomere attrition as a potential mechanism

Xin Lv, Xinyan Wang, Yalan Wang, Dezheng Zhou, Wen Li, John X. Wilson, Hong Chang, Guowei Huang,

https://doi.org/10.18632/aging.102461 pp 10356—10373

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Hypoxia-induced microRNA-10b-3p promotes esophageal squamous cell carcinoma growth and metastasis by targeting TSGA10

Qiang Zhang, Jingjing Zhang, Zhanzhao Fu, Lixin Dong, Yong Tang, Chunlei Xu, Haifeng Wang, Tao Zhang, Yue Wu, Chao Dong, Shasha Shao, Guangxia Wang,

https://doi.org/10.18632/aging.102462 pp 10374—10384

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Rotating magnetic field delays human umbilical vein endothelial cell aging and prolongs the lifespan of Caenorhabditis elegans

Jiangyao Xu, Kan Liu, Tingting Chen, Tianying Zhan, Zijun Ouyang, Yushu Wang, Wen Liu, Xiaoyun Zhang, Yang Sun, Gaixia Xu, Xiaomei Wang,

https://doi.org/10.18632/aging.102466 pp 10385—10408

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The anti-inflammation, anti-oxidative and anti-fibrosis properties of swertiamarin in cigarette smoke exposure-induced prostate dysfunction in rats

Jinglou Chen, Jianhua Liu, Yongfang Lei, Min Liu,

https://doi.org/10.18632/aging.102467 pp 10409—10421

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Large-scale analyses identify a cluster of novel long noncoding RNAs as potential competitive endogenous RNAs in progression of hepatocellular carcinoma

Mengjia Song, Ailin Zhong, Jieying Yang, Junyi He, Shaoyan Cheng, Jianxiong Zeng, Yue Huang, Qiuzhong Pan, Jingjing Zhao, Ziqi Zhou, Qian Zhu, Yan Tang, Hao Chen, Chaopin Yang, Yuan Liu, Xiaocong Mo, Desheng Weng, Jian-Chuan Xia,

https://doi.org/10.18632/aging.102468 pp 10422—10453

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Abnormal gut microbiota composition contributes to the development of type 2 diabetes mellitus in db/db mice

Fan Yu, Wei Han, Gaofeng Zhan, Shan Li, Xiaohong Jiang, Long Wang, Shoukui Xiang, Bin Zhu, Ling Yang, Ailin Luo, Fei Hua, Chun Yang,

https://doi.org/10.18632/aging.102469 pp 10454—10467

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Genome-wide association study of hippocampal atrophy rate in non-demented elders

Yu Guo, Wei Xu, Jie-Qiong Li, Ya-Nan Ou, Xue-Ning Shen, Yu-Yuan Huang, Qiang Dong, Lan Tan, Jin-Tai Yu,

https://doi.org/10.18632/aging.102470 pp 10468—10484

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Identification of functional tRNA-derived fragments in senescence-accelerated mouse prone 8 brain

Shuai Zhang, Hejian Li, Ling Zheng, Hong Li, Chengqiang Feng, Wensheng Zhang,

https://doi.org/10.18632/aging.102471 pp 10485—10498

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Melatonin modulates IL-1β-induced extracellular matrix remodeling in human nucleus pulposus cells and attenuates rat intervertebral disc degeneration and inflammation

Yan Zhang, Fan He, Zhi Chen, Qihang Su, Meijun Yan, Qiang Zhang, Jun Tan, Lie Qian, Yingchao Han,

https://doi.org/10.18632/aging.102472 pp 10499—10512

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Astaxanthin protects against osteoarthritis via Nrf2: a guardian of cartilage homeostasis

Kai Sun, Jiahui Luo, Xingzhi Jing, Jiachao Guo, Xudong Yao, Xiaoxia Hao, Yaping Ye, Shuang Liang, Jiamin Lin, Genchun Wang, Fengjing Guo,

https://doi.org/10.18632/aging.102474 pp 10513—10531

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Distinct effects of epirubicin, cisplatin and cyclophosphamide on ovarian somatic cells of prepuberal ovaries

Serena Marcozzi, Valerio Rossi, Giulia Salvatore, Francesca Di Rella, Massimo De Felici, Francesca Gioia Klinger,

https://doi.org/10.18632/aging.102476 pp 10532—10556

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Identification of prognostic genes in the acute myeloid leukemia microenvironment

Shaoxin Huang, Biyu Zhang, Wenyan Fan, Qihan Zhao, Lei Yang, Wang Xin, Denggang Fu,

https://doi.org/10.18632/aging.102477 pp 10557—10580

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Mixed-location cerebral microbleeds as a biomarker of neurodegeneration in a memory clinic population

Bibek Gyanwali, Muhammad Amin Shaik, Chuen Seng Tan, Henri Vrooman, Narayanaswamy Venketasubramanian, Christopher Chen, Saima Hilal,

https://doi.org/10.18632/aging.102478 pp 10581—10596

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Crucial role of serum response factor in renal tubular epithelial cell epithelial-mesenchymal transition in hyperuricemic nephropathy

Long Zhao, Chenyu Li, Bin Zhou, Congjuan Luo, Yanfei Wang, Lin Che, Jun Zhao, Yan Xu,

https://doi.org/10.18632/aging.102479 pp 10597—10609

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Ets2 suppresses inflammatory cytokines through MAPK/NF-κB signaling and directly binds to the IL-6 promoter in macrophages

Xianwei Ma, Zhengyu Jiang, Na Li, Wei Jiang, Peng Gao, Mingjin Yang, Xiya Yu, Guifang Wang, Yan Zhang,

https://doi.org/10.18632/aging.102480 pp 10610—10625

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Circ_0006332 promotes growth and progression of bladder cancer by modulating MYBL2 expression via miR-143

Mingshan Li, Yili Liu, Jie Liu, Wei Li, Ning Li, Dongwei Xue, Xiling Zhang, Ping Wang,

https://doi.org/10.18632/aging.102481 pp 10626—10643

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MYSM1-AR complex-mediated repression of Akt/c-Raf/GSK-3β signaling impedes castration-resistant prostate cancer growth

Jinbo Sun, Xiangnan Hu, Yongheng Gao, Qisheng Tang, Zhining Zhao, Wenjin Xi, Fan Yang, Wei Zhang, Yue Song, Bin Song, Tao Wang, He Wang,

https://doi.org/10.18632/aging.102482 pp 10644—10663

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Competing endogenous network analysis identifies lncRNA Meg3 activates inflammatory damage in UVB induced murine skin lesion by sponging miR-93-5p/epiregulin axis

Nan Zhang, Zhou Zhong, Yujia Wang, Li Yang, Fengbo Wu, Cheng Peng, Wei Huang, Gu He,

https://doi.org/10.18632/aging.102483 pp 10664—10683

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Disrupted brain functional hub and causal connectivity in acute mild traumatic brain injury

Fengfang Li, Liyan Lu, Huiyou Chen, Peng Wang, Yu-Chen Chen, Hong Zhang, Xindao Yin,

https://doi.org/10.18632/aging.102484 pp 10684—10696

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MAP2K4 interacts with Vimentin to activate the PI3K/AKT pathway and promotes breast cancer pathogenesis

Shu Liu, Juan Huang, Yewei Zhang, Yiyi Liu, Shi Zuo, Rong Li,

https://doi.org/10.18632/aging.102485 pp 10697—10710

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p62-DNA-encoding plasmid reverts tumor grade, changes tumor stroma, and enhances anticancer immunity

Franco M. Venanzi, Vladimir Gabai, Francesca Mariotti, Gian Enrico Magi, Cecilia Vullo, Albert A. Sufianov, Sergey I. Kolesnikov, Alexander Shneider,

https://doi.org/10.18632/aging.102486 pp 10711—10722

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T cells and immune functions of plasma extracellular vesicles are differentially modulated from adults to centenarians

Ainhoa Alberro, Iñaki Osorio-Querejeta, Lucía Sepúlveda, Gorka Fernández-Eulate, Maider Mateo-Abad, Maider Muñoz-Culla, Susana Carregal-Romero, Ander Matheu, Itziar Vergara, Adolfo López de Munain, Matías Sáenz-Cuesta, David Otaegui,

https://doi.org/10.18632/aging.102517 pp 10723—10741

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Reviews

Association of genes with phenotype in autism spectrum disorder

Sabah Nisar, Sheema Hashem, Ajaz A. Bhat, Najeeb Syed, Santosh Yadav, Muhammad Waqar Azeem, Shahab Uddin, Puneet Bagga, Ravinder Reddy, Mohammad Haris,

https://doi.org/10.18632/aging.102473 pp 10742—10770

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Deep biomarkers of aging and longevity: from research to applications

Alex Zhavoronkov, Ricky Li, Candice Ma, Polina Mamoshina,

https://doi.org/10.18632/aging.102475 pp 10771—10780

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Correction

Correction for: Proteomics-based identification of different training adaptations of aged skeletal muscle following long-term high-intensity interval and moderate-intensity continuous training in aged rats

Fang-Hui Li, Lei Sun, Da-Shuai Wu, Hao-En Gao, Zhu Min,

https://doi.org/10.18632/aging.102596 pp 10781—10782

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