Research Paper Volume 11, Issue 22 pp 9982—9999

Circular RNA hsa_circ_0000515 acts as a miR-326 sponge to promote cervical cancer progression through up-regulation of ELK1

Figure 8. Image showing the underlying mechanism of how hsa_circ_0000515 is involved in the progression of cervical cancer. Hsa_circ_0000515 acts as a ceRNA of miR-326 to upregulate ELK1, thereby resulting in promotion of cervical cancer cell proliferation and invasion, and inhibition of apoptosis and autophagy, as reflected by up-regulated PCNA, MMP-9 expression, and down-regulated LC3 expression.