Research Paper Volume 11, Issue 22 pp 10183—10202

Development and validation of a metastasis-associated prognostic signature based on single-cell RNA-seq in clear cell renal cell carcinoma

Figure 2. Identification of prognostic metastasis associated genes. (A, B) We conducted the LASSO method based on glmnet package and identified the 17 prognostic genes in TCGA training cohort, where the optimal cutoff value was -4 and the minimum account of genes was 17. © Meanwhile, we also illustrated the significantly differential expressions of 17 prognostic genes in two clusters via bubble plot.