Research Paper Volume 11, Issue 22 pp 10183—10202

Development and validation of a metastasis-associated prognostic signature based on single-cell RNA-seq in clear cell renal cell carcinoma

Figure 4. Correlation analysis between MAGs with other clinical variables and predictive efficiency of MAGs in PFS. (AE) Kruskal-Wallis test revealed that increasing MAGs-score correlated with higher T stages (P = 7.586e-09), higher positive rate of lymph nodes (P = 0.005), advanced metastatic stages (P = 1.572e-06), poor pathological stages (P = 1.699e-08) and progressive tumor grades (P = 1.643e-11). (F, G) Moreover, the MAGs signature possessed superior significance in 5-year PFS prediction with AUC = 0.752 in total TCGA-KIRC cohort and patients with high MAGs-score suffered more hazards in tumor recurrence or progression with log-rank test of P = 0. (H, I) Correlation analysis of MAGs with T, M stages in ICGC validation cohort.