Research Paper Volume 11, Issue 22 pp 10183—10202

Development and validation of a metastasis-associated prognostic signature based on single-cell RNA-seq in clear cell renal cell carcinoma

Figure 6. Differential landscape of somatic mutation burden between high and low MAGs-nomogram levels. (A) The mutational landscape reflected that mutated events occurred more frequently in high Nomogram-score group than that in low group. Besides, the Chi-square test revealed that VHL, PBRM1, SETD2 and BAP1 especially harbored more mutants compared with that in low risk group. (B) Wilcoxon rank-sum test suggested that the MAGs-nomogram risk scores were significantly higher in high TMB group than that in low TMB group (P = 2.875e-05). (C, D) Additionally, we found that higher TMB levels were associated with more risks of progression events with P = 0.01 and worse OS outcomes with P = 0.035.