Research Paper Volume 11, Issue 22 pp 10220—10241

Circular RNA CircCCNB1 sponges micro RNA-449a to inhibit cellular senescence by targeting CCNE2

Figure 1. Expression profile of SAC-RNAs and mRNA in proliferating and prematurely senescent 2BS fibroblasts. (A) Volcano plot showing CircRNA expression in young and prematurely senescent 2BS fibroblasts. The red and green dots represent CircRNAs with statistically significant differences in expression. (B) Length distributions of the identified CircRNAs by RNA-Seq. x-axis: length of CircRNAs detected in this study. y-axis: number of CircRNAs classified according to length. (C) Pie chart showing the percentage of CircRNAs derived from different genomic regions. (D) Distributions of identified CircRNAs along the chromosomes. (E and F) Cluster heatmaps showing the five most increased and decreased CircRNAs and representative differentially expressed mRNAs. Each column indicates a sample and each row indicates an individual CircRNA or mRNA. (G) Kyoto Encyclopedia of Genes and Genomes (KEGG) of differentially expressed mRNAs.