Research Paper Volume 11, Issue 22 pp 10242—10251

Studies on APP metabolism related to age-associated mitochondrial dysfunction in APP/PS1 transgenic mice

Figure 6. Schematic representation of the potential mechanisms involved in Aβ-associated mitochondrial dysfunction in APP/PS1 mice. In the presence of Aβ, mitochondrial dysfunction has been shown to be associated with mitochondrial ATP production and cell signaling cascades, eventually leading to apoptosis. The red and blue arrows visualize the increased or decreased processes of APP/PS1 mice proteins compared to the control C57 mice, respectively.