Research Paper Volume 11, Issue 22 pp 10316—10337

Multi-omics analysis reveals epithelial-mesenchymal transition-related gene FOXM1 as a novel prognostic biomarker in clear cell renal carcinoma

Figure 4. Aberrant DNA methylation of EDCGs affected their expression in ccRCC. (A) The landscape of differentially methylated regions (DMRs) and expression quantitative trait methylations (eQTMs) in human genome (hg19). 186 DMRs not in promoter were shown using gray dots. The red symbols (both circle and square) represent the higher status (either a higher status of DNA methylation or a higher status of expression), while the blue symbols represent the lower/opposite status. (B) Gene set enrichment analysis between localized ccRCC and controls.