Research Paper Volume 11, Issue 22 pp 10316—10337

Multi-omics analysis reveals epithelial-mesenchymal transition-related gene FOXM1 as a novel prognostic biomarker in clear cell renal carcinoma

Figure 7. cg00044170, FOXM1 and the hybrid signature for diagnosis of ccRCC. (A) Receiver operating characteristic (ROC) curves of eQTM (cg00044170 of FOXM1) in classifying all/localized tumors and normal. (B) ROC curves of FOXM1 (C) The calculation of epsilon value to simultaneously consider expression of genes and methylation of eQTMs. (D) ROC curves of eQTM-gene hybrid signature (cg00044170 and FOXM1) in classifying all/localized tumors and normal. (E) The distribution of epsilon values of patients in the training set. The median epsilon value was used as cut-off point to divide ccRCC patients into high- and low-group. The datasets named “tumors” (the whole dataset) are stage I/II tumors and stage III/IV tumors, while the datasets named “localized tumors” (the subset) are stage I/II tumors.