Research Paper Volume 11, Issue 22 pp 10356—10373

Folic acid delays age-related cognitive decline in senescence-accelerated mouse prone 8: alleviating telomere attrition as a potential mechanism

Figure 6. FA supplementation improved mitochondrial biogenesis and function in brain of SAMP8 mice. Mice were assigned to treatment groups as described in Figure 1. (A) Relative mitochondrial DNA copy number indicated by mtDNA/nDNA ratio [F(5,54) = 43.946, P<0.001]. (B) Mitochondrial DNA deletions indicated by ND1/ND4 ratio [F(5,54) = 59.644, P<0.001]. (C) Mitochondrial function indicated by ATP level [F(5,54) = 123.771, P<0.001]. Data are expressed as mean ± SD (n= 10 mice/group). *P<0.05 compared with FA-N group. #P<0.05 compared with Con-Y group.