Figure 1. (A) HE and sirius red staining (n=6 per group, magnification ×200, scale bar=100 μm) for the evaluation of prostate morphological changes and collagen deposition. Hollow arrow: irregular bulges. Solid arrow: collagen deposition. (B) Prostatic mRNA levels (n=4 per group) of Col1A1 and Col3A1, as well as the expression (n=3 per group) of Col-I and Col-III. (C) Prostatic content of Hyp (n=6 per group). **p<0.01, *p<0.05 compared to the CS group. A: vehicle, B: CS, C: CS-32 mg/kg swertiamarin, D: CS-16 mg/kg swertiamarin.