Research Paper Volume 11, Issue 22 pp 10454—10467

Abnormal gut microbiota composition contributes to the development of type 2 diabetes mellitus in db/db mice

Figure 5. Alterations in the gut microbiota profiles of pseudo-germ-free mice after transplantation from db/db and m/m mice. (A) Unweighted UniFrac diversity distance; (B) Ace index (F3,24 = 3.571, P < 0.05); (C) Chao index (F3,24 = 3.415, P < 0.05); (D) Shannon index (F3,24 = 0.6078, P > 0.05); (E) Simpson index (F3,24 = 1.305, P > 0.05); (F) PCA analysis of the data of gut bacteria (PC1 versus PC2); (G) PLS-DA analysis of the data of gut bacteria. Data are shown as mean ± SEM values (n=7). *P < 0.05, **P < 0.01, ***P < 0.001. CONT, control; PCA, principal component analysis; PLS-DA, partial least squares-discriminant analysis; NS, not significant; SEM, standard error of the mean.