Research Paper Volume 11, Issue 22 pp 10468—10484

Genome-wide association study of hippocampal atrophy rate in non-demented elders

Figure 2. Hippocampal atrophy rates of different genotypes. The y-axis showed the hippocampal atrophy rate and the x-axis corresponded to different genotypes. The effect of genotypes on hippocampal atrophy rate was examined with a multiple linear regression model using age, gender and diagnosis as covariates. (A) The minor allele of rs4420638 (G) showed association with hippocampal atrophy rate in a dose-dependent manner (P = 3.20 × 10-7). (B) The minor allele of rs157582 (T) showed association with hippocampal atrophy rate in a dose-dependent manner (P = 1.23 × 10-8).