Research Paper Volume 11, Issue 22 pp 10499—10512

Melatonin modulates IL-1β-induced extracellular matrix remodeling in human nucleus pulposus cells and attenuates rat intervertebral disc degeneration and inflammation

Figure 2. Effects of 0, 100, 200, 400 μM melatonin for 24 h on collagen II (COL2), aggrecan and MMP-3 in NPCs. (A) Protein levels of COL2, aggrecan, MMP-3. (B) Semi-quantitative analysis of COL2 levels (n=3). (C) Semi-quantitative analysis of aggrecan levels (n=3). (D) Semi-quantitative analysis of MMP-3 levels (n=3). The values are expressed as mean ± SD. *P<0.05 vs control group; **P<0.01 vs control group.