Review Volume 11, Issue 22 pp 10742—10770

Association of genes with phenotype in autism spectrum disorder

Figure 4. Wnt and Ca2+ pathway in ASD. Wnt binds to LRP5/LRP6 receptor and stabilizes β-catenin in the nucleus and cytoplasm. High influx of Ca2+ ions causes activation of CAMK and CREB genes which initiates transcription in the postsynaptic side. Genes mutated in ASD are shown in red boxes.