Research Paper Volume 11, Issue 23 pp 10839—10860

HIF-2α upregulation mediated by hypoxia promotes NAFLD-HCC progression by activating lipid synthesis via the PI3K-AKT-mTOR pathway

Figure 6. Hypoxia-induced HIF-2α overexpression promotes STAM mouse tumour development and lipid accumulation in vivo, which can be rescued by an mTOR inhibitor. (A). Gross specimens from STAM mice of different groups. (B) Images of liver stained by HE and Oil red O staining. (C) The numbers of tumours on the liver surface of different STAM mice (n = 10 mice/group). d. In the tumour size analysis, the largest three tumours found at a random location in the liver were used.