Research Paper Volume 11, Issue 23 pp 10839—10860

HIF-2α upregulation mediated by hypoxia promotes NAFLD-HCC progression by activating lipid synthesis via the PI3K-AKT-mTOR pathway

Figure 8. HIF-2α induced lipid synthesis and exacerbated lipid accumulation in STAM mice in vivo. (A), Western blot analysis of FASN and ACC1 expression in STAM mice of different groups. β-actin was used as the loading control. Densitometric analyses of the band intensity ratios for FASN/β-actin and ACC1/β-actin.