Research Paper Volume 11, Issue 23 pp 10902—10922

The long non-coding RNA SNHG12 promotes gastric cancer by activating the phosphatidylinositol 3-kinase/AKT pathway

Figure 1. SNHG12 is upregulated in human GC and is associated with a poor prognosis. (A) Hierarchical heat map of differentially expressed genes between GC and para-cancerous tissues from the Gene Expression Omnibus database. Blue denotes downregulated genes and red denotes upregulated genes. (B) SNHG12 levels were detected in unpaired and paired GC tissues from TCGA, GSE37023 and GSE51575 cohorts. (C, D) Kaplan-Meier analysis of the association between SNHG12 expression and overall survival in GC patients, based on TCGA and GSE15459 cohorts. (E, F) FISH analysis of the subcellular localization and expression of SNHG12 in GC and para-cancerous tissues. The nucleus was labeled with DAPI (blue) and SNHG12 was labeled with a probe (green). Scale bar: 20 μm. (G) Kaplan-Meier analysis of the association between SNHG12 expression and overall survival in GC patients, based on the tissue microarray. ***P<0.001, ****P<0.0001.