Research Paper Volume 11, Issue 23 pp 10902—10922

The long non-coding RNA SNHG12 promotes gastric cancer by activating the phosphatidylinositol 3-kinase/AKT pathway

Figure 5. SNHG12 is involved in the PI3K/AKT pathway in GC cells. (A) Hierarchical heat map of differentially expressed genes between si-NC- and si-SNHG12-transfected MGC-803 cells. (B) KEGG pathway enrichment analysis revealed that the differentially expressed genes were mainly enriched in eight pathways. (C) Gene Ontology analysis of the differentially expressed genes. (D) The prediction results demonstrated that SNHG12 was likely to bind to PIK3R1. (E) An RNA pulldown assay was performed to confirm that SNHG12 could bind to PIK3R1 in AGS and MGC-803 cells.