Research Paper Volume 11, Issue 23 pp 10923—10938

Kainic acid hyperphosphorylates tau via inflammasome activation in MAPT transgenic mice

Figure 8. Bay11-7082 mitigates KA-induced memory deficits in the Morris water maze test. (A, B) During the first 2 days of visible platform tests, the KA and Bay11-7082 treated and control MAPT Tg mice exhibited a similar latency to escape onto the visible platform. P > 0.05 with Student’s t-test. (C, D) In the hidden platform tests, KA-treated MAPT mice showed a longer latency and length to escape onto the hidden platform on the 3rd and 4th days, which was ameliorated by the addition of Bay11-7082 on the 4th day. *P < 0.05; ***P < 0.001 vs. the control group; ##P < 0.01; ###P < 0.001 vs. the KA-treated group by ANOVA. (E) In the probe trial on the 7th day, the KA-treated MAPT Tg mice traveled into the third quadrant, where the hidden platform was previously placed, significantly less times than controls, which was improved by the treatment with Bay11-7082. **P < 0.01 vs. the control group; ## P < 0.01 vs. the KA-treated group by ANOVA.