Research Paper Volume 11, Issue 23 pp 11010—11029

Reactive oxygen species metabolism-based prediction model and drug for patients with recurrent glioblastoma

Figure 7. Gallic acid was screened out as a TMZ chemotherapy sensitizer in TMZ-resistant glioma cells. (A) Gallic acid showed the strongest ROS scavenging ability in 12 kinds of herbs extracts in U87 TMZ-R. Herb1: Atractylenolide I, Herb2: Curcumin, Herb3: Gallic acid, Herb4: Nuzhenide, Herb5: Pachymic acid, Herb6: Pulchinenoside C, Herb7: Paeoniflorin, Herb8: Curcumol, Herb9: Polydatin, Herb10: Danshensu, Herb11: Artemisinin, Herb12: Scutellarin. (B) The ROS scavenging capacity increased with increasing concentration of gallic acid in U87 TMZ-R. (C) The cytotoxicity increased with increasing concentration of gallic acid in HA, U87, and U87 TMZ-R. (D) A low dose of gallic acid (20 μM and 40 μM) could restore chemosensitivity of U87 TMZ-R to temozolomide.