Research Paper Volume 11, Issue 23 pp 11040—11053

Sphingosine-1-phosphate promotes PDGF-dependent endothelial progenitor cell angiogenesis in human chondrosarcoma cells

Figure 6. Schematic diagram summarizes the mechanisms of S1P-promoted tumor angiogenesis in chondrosarcoma. S1P facilitates PDGF-A production via the Ras/Raf/MEK/ERK/AP-1 signaling pathway in human chondrosarcoma cells and subsequently induces EPC angiogenesis.