Research Paper Volume 11, Issue 23 pp 11054—11072

EGFR-specific CAR-T cells trigger cell lysis in EGFR-positive TNBC

Figure 6. EGFR-specific CAR-T cells inhibited EGFR-expressing TNBC tumor growth in CLDX mouse model. Compared to con-CAR-T cells, EGFR-CAR-1 and EGFR-CAR-2 T cells decreased the weights and volumes of tumors induced by (A, B) HS578, (D, E) MDA-MB-468, and (G, H) MDA-MB-231 TNBC cells, but did not affect body weight (C, F, I). Error bars represent means ± SEM. T-tests were used for statistical analysis; *p < 0.05, ** p < 0.01, ***p < 0.001.